The topic of this article will revolve around the Tesamorelin peptide and its potential connection to adipose tissue.
Tesamorelin is a synthetic counterpart of the growth hormone-releasing hormone (GHRH), and it has been studied for its potential to promote the natural production of growth hormone (GH) and its release into the bloodstream. Tesamorelin was first synthesized by research teams hoping to explore its potential to mitigate the effects of Lipodystrophy. [i]. Subjects with Lipodystrophy, among other symptoms, have higher levels of fat, a problem that studies suggest Tesamorelin may help to address.
Research is being conducted on the peptide for uses other than fat redistribution and loss. Studies suggest some of these applications include the potential to mitigate moderate cognitive impairment, help heal nerves following damage, and potentially promote the elimination of excess fat.
What Potential Does Tesamorelin Have?
Research suggests Tesamorelin’s structure and actions are similar to GHRH’s (the growth hormone-releasing factor). However, despite their similarities, Tesamorelin is a peptide rather than a protein. It comprises 44 amino acids and a trans-3-hexenoic acid group [ii]. Due to this latter factor, Tesamorelin is thought to be more stable and potentially exhibit a longer half-life than natural GHRH.
Studies suggest Tesamorelin, an analog of GHRH, may bind to the anterior pituitary gland’s growth hormone-releasing hormone receptors (GHRHr). This may cause the somatotropic cells in the anterior pituitary gland to produce and secrete growth hormone (GH) throughout the body [iii].
Researchers speculate one of the essential chemical signals released during the development of new tissue and during the reparation of damaged tissue is growth hormone, considered a potent anabolic hormone. Research suggests it may have a role in various processes, including the formation of new muscle, the healing of injured tissue, and even the breakdown of fat. GH levels in the body begin high and decline with maturation. This deterioration process may affect a test subject’s mobility and time to recover from an injury [iii].
What follows is a summary of what studies have to say regarding the potential properties of Tesamorelin and its applications.
Tesamorelin and Adipose Tissue
Professionals hypothesize Tesamorelin’s primary potential may be to mitigate the effects of Lipodystrophy present in HIV-positive test subjects, and this has been studied in clinical settings. This disorder involves the buildup of fatty tissue in the upper back and around the abdomen [iv]. Clinical studies have hypothesized Tesamorelin’s potential to mitigate HIV action in test subjects with Lipodystrophy.
Research has speculated that Tesamorelin may cause lipolysis, often known as fat loss, in test subjects under these conditions. Tesamorelin was hypothesized by researchers to potentially dramatically reduce subcutaneous adipose tissue in HIV-positive test subjects with Lipodystrophy and excess fat around the abdomen [v]. This reduction was determined to be 15 percent. On the other hand, subjects in the control group appeared to have a five percent rise in their overall body fat percentage. Tesamorelin was suggested to reduce insulin resistance and cholesterol levels in the research that hypothesized it to enhance cholesterol levels. [v]
These findings do not appear to be an exception; a study of four randomized controlled studies [vi] has suggested that they are consistent. As suggested by the study, Tesamorelin may possibly lower adipose tissue at an apparent four times more effective rate than any other peptide studied in comparison. [vii]
Tesamorelin and Peripheral Nerves
Injuries, surgical procedures, and even diabetes are all potential causes of injury to the peripheral nerves, which may lead to a loss of motor and sensory function. As nerve cells are considered to be difficult to regenerate, very few options exist to researchers to mitigate this loss. Despite this, intriguing research has suggested that Tesamorelin and other GHRH secretagogues may boost the amount to which nerves can renew themselves [viii].
More study is needed to fully understand its potential applications in science. Peptides for sale online are restricted to usage in research and educational institutes. These peptides are available for research purposes through Biotech Peptides. The substances discussed here are approved for ingestion by humans or animals. Compounds used in scientific research should never be used outside of a laboratory. It is forbidden to make a personal introduction of any type. Sales are restricted to verified professionals and active scientists only. This article’s information is meant only for educational purposes.
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