The topic of this article will revolve around the Thymosin Beta 4 peptide and the extensive vision research it has been a part of.
TB-500, also known as Thymosin beta 4, is an oligopeptide consisting of 43 amino acids with a molecular weight of around 4.9 kDa. The only cells researchers have suggested it doesn’t permeate are erythrocytes (red blood cells).
The peptide was first identified as a protein isolate from the thymus gland of mammals. It is considered a member of the Thymosin family, consisting of acidic, lightweight molecules that may exhibit action during cell production.
Studies suggest that the apparent ability of single monomers (or actin proteins) to polymerize into thin strands may be inhibited, allowing research teams to control the motility and differentiation of cells.
Studies speculate Thymosins, on the other hand, may be responsible for the assembly of actin monomers, which either allow or prohibit the formation of future filaments.
The differentiation of one cell to another, say, a pluripotent stem cell into a neuron or a bone cell, may possibly be affected by this.
Scientists hypothesize that Thymosin-like molecules (with Thymosin beta-4 being the most common in mammals) might play a significant role in postnatal development and the regeneration of (some but not all) tissues. Because of its possible action on actin, TB-500 has been studied for its potential control of cell migration and the development of new blood vessels.
This indicates that the protein may be able to mend damaged tissue. TB-500 (Thymosin Beta 4) is a synthetic peptide that may only be used in research settings.
Thymosin Beta 4 (TB-500) Peptide Research
Several clinical studies have posited that TB-500 exhibits potential to promote tissue regeneration and repair. Research suggests scar formation, microbial development, cell death, and inflammation are all processes that Thymosin beta 4 may inhibit or possibly stop altogether.
Extracorporeal TB-500 may potentially hasten the recovery of damaged ocular, dermal, and cardiac tissues after injury, as suggested by comprehensive research studies.
Scientists hypothesize the peripheral nervous system, the brain, the heart, and the spinal cord are just some of the numerous tissues that this peptide may contribute action to and possibly regenerate. Researchers suggest TB-500 may exhibit anti-inflammatory potential as well.
Furthermore, it has been speculated to inhibit NO production and prostaglandin EP4 release in cell models subjected to ROS.
However, professionals speculate it may increase pro-inflammatory chemokines and numerous interleukins in periodontal cells. Since these compounds are osteoclastogenic as well, TB-500 may perhaps exhibit action in regulating bone synthesis.
One research study suggested the peptide may inhibit NF-B activation in murine macrophages. The anti-inflammatory peptide fragment acSDKP, a TB-500 derivative, is reported released in response to TB-500. A variety of important aspects control this fragment’s metabolism.
Rat kidney tissue was combined with TB 500, which resulted in a considerable increase in acSDKP7 secretion. Intricate regulatory mechanisms, including peptidases that break only the molecules of certain pieces, such as TB-500 hydrolysis by meprin-alpha, appear to be required before acSDKP may be separated from it.
Studies suggest Thymosin beta-4 research may be useful in examining fibrotic scarring in various organs. In addition, acSDKP may be effective in reducing renal fibrosis in animals.
Researchers speculate the up-regulation of TB-500 seems to be linked to the activation of hepatic stellate cells. Research suggests TB-500 is a peptide that may be involved in complex regulating and developmental processes.
It seems that TB-500 may have a role in the regulation of tissue regeneration, inflammation, and cell differentiation. This indicates it possible utilization on test models of conditions such as rheumatoid arthritis, aberrant fibrosis, postnatal phases of development, and osteolytic inflammation.
TB-500 Peptide and Vision
Studies examining nimal test models indicate that TB 500 may mitigate ocular injuries caused by ultraviolet radiation, alkali, secondhand smoke, heptanol debridement, and ethanol.
These studies suggest that TB 500-induced cell migration may be responsible for the healing in each circumstance where it was present. Rapid healing was reported in the affected eyes, and an uptick in migration was reported after this peptide was present in the test model.
More study is needed to fully understand its potential applications in science. TB-500 is restricted to usage in research and educational institutes. These peptides are available for research purposes through Core Peptides. The substances discussed here are approved for ingestion by humans or animals. Compounds used in scientific research should never be used outside of a laboratory. It is forbidden to make a personal introduction of any type. Sales are restricted to verified professionals and active scientists only. This article’s information is meant only for educational purposes.
[i] Kim J, Wang S, Hyun J, et al. Hepatic Stellate Cells Express Thymosin Beta 4 in Chronically Damaged Liver. PloS one journal, 2015.
[ii] Philip D, Goldstein AL, Kleinman HK. Thymosin beta4 promotes angiogenesis, wound healing, and hair follicle development. Mechanisms of ageing and development, 2004.
[iii] Lee S-I, Yi J-K, Bae W-J, et al. Thymosin Beta-4 Suppresses Osteoclastic Differentiation and Inflammatory Responses in Human Periodontal Ligament Cells. PloS one journal, 2016.
[iv] Conte E, Genovese T, Gili E, et al. Protective effects of thymosin beta4 in a mouse model of lung fibrosis. Annals of the New York Academy of Sciences, 2012.
[v] Sosne G, Kleinman HK; Primary Mechanisms of Thymosin ?4 Repair Activity in Dry Eye Disorders and Other Tissue Injuries. Invest. Ophthalmol. Vis. Sci, 2015.
[vi] Goldstein AL, Hannappel E, Sosne G & Kleinman HK. Thymosin ?4: a multi-functional regenerative peptide. Basic properties and clinical applications, Expert Opinion on Biological Therapy, 2012.
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